This is your opportunity to own a high-visibility commercial lot in the heart of Sanibel. Located along the island’s main thoroughfare in the General Commercial (GC) district, this property offers exceptional exposure and strong traffic counts, making it an ideal site for a restaurant, retail space, or professional office. Formerly home to beloved local favorite Sweet Melissa’s Café, this site presents an exciting opportunity to bring new life to a well-known business location. For buyers with a restaurant vision, there is an option to obtain existing design plans, helping save significant time and expense in the redevelopment process. With frontage along the island’s walking and biking path and constant visibility to both incoming and outgoing traffic, this property delivers outstanding exposure for any business or investment. Centrally positioned in a pedestrian-friendly setting near shops, hotels, and island amenities, it offers an exceptional location for entrepreneurs and investors ready to make their mark on Sanibel’s commercial landscape. Don’t miss this rare opportunity to invest in one of Southwest Florida’s most sought-after island destinations.
Courtesy of Pfeifer Realty Group LLC
The data relating to real estate for sale on this limited electronic display comes in part from the Southwest Florida MLS Listing Service. Properties listed with brokerage firms other than our company are marked with the BR Program Icon or the BR House Icon and detailed information about them includes the name of the Listing Brokers. The properties displayed may not be all the properties available through the BR Program. The source of this real property information is the copyrighted and proprietary database compilation of the participating Southwest Florida MLS organizations and is Copyright 2026 Southwest Florida MLS organizations. All rights reserved. The accuracy of this information is not warranted or guaranteed. This information should be independently verified if any person intends to engage in a transaction in reliance upon it. Some properties that appear for sale on this limited electronic display may no longer be available. Data last updated .